By R. M. MacKie (auth.), Dirk J. Ruiter MD, Kees Welvaart MD, Soldano Ferrone MD (eds.)
In contemporary years a lot growth has been made in wisdom and figuring out of the biology of cutaneous cancer. during this admire etiological components, prognostic components, antigen expression of cancer cells, immune reaction and mechanisms of metastasis formation must be pointed out. it's the objective of this ebook to provide a assessment on primary points, prognosis and diagnosis, and therapy of cutaneous cancer and precursor lesions. furthermore, formerly unpublished new facts are offered. A post-graduate Boerhaave direction "Cutaneous cancer and Precursor Lesions" used to be held at Leiden college on 12 and thirteen April,. 1984. The court cases are contained during this quantity. The editors wish to thank all audio system and chairpersons at the direction, the Boerhaave Committee for its contribution to the service provider of the path, Upjohn Nederland for its monetary help and Mrs. I.A. Kruyff for her secretarial suggestions. Dirk Ruiter, Kees Welvaart and Soldano Ferrone, Leiden and Valhalla (NY), June, 1984. VII CONTENTS Preface v Contents VII record of First Authors with Co-Authors XI half I: primary facets. The epidemiology of cancer R.M. MACKIE The molecular biology of carcinogenesis nine A.W.M. VAN DER KAMP AND N.G.J. JASPERS 19 Human cancer linked antigens pointed out with monoclonal antibodies: characterization and power scientific program P.G. NATALI, R. CAVLIERE, M. MATSUI, G. BURAGGI, L. CALLEGARO, and S. FERRONE mobile and molecular parameters of tumor development in 38 human malignant cancer J. BRUEGGEN, E.B. BROECKER, L. SUTER, okay. REDMANN, and C.
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Immunodermatology (London), Mac Donald, in press Tsuruo T, Fidler IJ. 1981. Differences in drug sensitivity among tumor cells from parental tumors, selected variants, and spontaneous metastases. Cancer Res 41: 3058 Diala ES, Cheah MSC. Rowitch D, Hoffman RM. 1983. Extent of DNA methylation in human tumor cells. J Natl Cancer Inst 71:755. Natali PG, Cavaliere R, Bigotti A, Nicotra MR, Russo C, Ng AK, Giacomini P, Ferrone S. 1983. Antigenic heterogeneity of surgically removed primary and autologous metastatic human melanoma lesions.
The impact of monoclonal antibodies on the study of human malignant melanoma. J. Cutan. Pathol. 10:514. 7. Wi lson BS, Imai K, Natal i PG, Ferrone S. 1981. Distribution and molecular characterization of a cell-surface and a cytoplasmic antigen Int. detectable in human melanoma cells with monoclonal antibodies. J. Cancer 28:293. 8. Wilson BS, Giacomini P, Imai K, Natali PG, Nakanishi T, Ruberto G, Ferrone S. 1982. Human melanoma associated antigens identified with monoclonal antibodies: Structural profile and potential usefulness in immuno-diagnosis and immunotherapy, La Ricerca elin.
48 The phenotypic instability of melanoma cells as found here in vitro reflects in part the described heterog'eneity that can be detected in malignant melanoma biopsies. 4. PHENOTYPING OF MELANOMA BIOPSIES AND ITS RELATION TO TUMOR PROGRESSION It is still a question of outmost interest, if it is possible to define surface markers which define a certain stage of malignancy, as it can be found in experimental tumor systems (42). In human malignant melanoma several melanoma-associated antigens have been described; but a histological survey in situ on melanoma biopsies revealed that most of them reacted to a high percentage with nevi, primary and metastatic lesions of melanoma (for review see 9).