Download Antibody Expression and Production by Thomas Jostock (auth.), Mohamed Al-Rubeai (eds.) PDF

By Thomas Jostock (auth.), Mohamed Al-Rubeai (eds.)

Engineered antibodies presently characterize over 30% of biopharmaceuticals in scientific trials and their overall world wide revenues proceed to extend considerably. the significance of antibody purposes is mirrored of their expanding scientific and business purposes in addition to within the development of validated and rising creation innovations. This quantity offers distinct insurance of the new release, optimization, characterization, construction and purposes of antibody. It offers the required theoretical historical past and outline of tools for the expression of antibody in microbial and animal mobilephone cultures and in transgenic animals and crops. there's a powerful specialize in these matters on the topic of the construction of intrabodies, bispecific antibody and antibody fragments and likewise to novel purposes in melanoma immunotherapy.

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Dubel, S. & Jostock, T. (2007a) A comparative study of different vector designs for the mammalian expression of recombinant IgG antibodies. J Immunol Methods, 318, 113–24. , Jostock, T. & Dubel, S. (2007b) Analysis of IgG heavy chain to light chain ratio with mutant Encephalomyocarditis virus internal ribosome entry site. Protein Eng Des Sel, 20, 491–6. , Perez, C. , Vanderbyl, S. & Ledebur, H. , Jr. (2004) A mammalian artificial chromosome engineering system (ACE System) applicable to biopharmaceutical protein production, transgenesis and gene-based cell therapy.

S. (2007) Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. BMC Genomics, 8, 229. , Opstelten, D. , Logtenberg, T. & Bout, A. c6. Biotechnol Prog, 19, 163–8. Jostock, T. (2009) Reducing cycle time for cell line development. Cell Line Development and Engineering Conference. Berlin, Informa. , Kallen, K. , Rose-John, S. & Mullberg, J. (1999) Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6.

Nett, J. , Stadheim, T. , Wildt, S. & Gerngross, T. U. (2003) Production of complex human glycoproteins in yeast. Science, 301, 1244–6. Hanania, E. , Bodzin, L. , Palsson, B. O. & Koller, M. R. (2005) Automated in situ measurement of cell-specific antibody secretion and laser-mediated purification for rapid cloning of highly-secreting producers. Biotechnol Bioeng, 91, 872–6. Holmes, P. & Al-Rubeai, M. (1999) Improved cell line development by a high throughput affinity capture surface display technique to select for high secretors.

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