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By Shayne C. Gad

Although i've got but to learn the publication in its entirety, i've got skimmed via numerous chapters & i locate that a lot of the recommendations seem to be written in redundancy. might be i've got excessive expectancies, yet might be ideas which are played within the comparable demeanour among species will be consolidated and referenced. the knowledge for genuine toxicology within the numerous species is especially precious.

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Transat. 2, 359–377. Wong, K. (1976). Species differences in the conjugation of 4-hydroxy-3-methoxypheylethanol. Biochem. J. 158, 33–37. Ziegler, D. M. (1988). Flavin-containing monooxygenase: Catalytic mechanism and specificities. Drug Metab. Rev. 19, 1–32. fm Page 19 Thursday, August 31, 2006 10:30 PM CHAPTER 2 The Mouse Toxicology: Shayne C. Gad Gad Consulting Services Pathology: Charles H. Frith Toxicology Pathology Associates Dawn G. Goodman PATHCO, Inc. Byron G. Boysen Hazleton Wisconsin, Inc.

McCally, A. , Farmer, A. , and Loomis, E. C. (1933). Corneal ulceration following use of lash lure. A. 101(20), 1561. , and Stocker, K. (1989). Review article: On the significance of animal experiments in toxicology. Toxicon 27, 91–104. , and Kamataki, T. (1989). Interspecies homology of cytochrome P-450: Inhibition by anti-P-450-male antibodies of testosterone hydroxylases in liver microsomes from various animal species including man. Jpn. J. Pharmacol. 49, 365–374. , and Miller, J. (1949). The reductive cleavage of 4-dimethylaminoazobenzene by rat liver: The intracellular distribution of the enzyme system and its requirement for triphosphoropyridine nucleotide.

Mice respond to low temperature by nonshivering thermogenesis, and resting mice can generate heat at a rate about triple their basal metabolic rate. Group-housed mice can compensate for low temperatures by huddling in a group, a practice that is more effective in a solid-bottom cage containing bedding. Mice have a limited capacity to compensate for excessive heat, and do so primarily by vasodilation of the ears to increase heat loss, and by increasing body temperature by several degrees. In the wild, mice adapt to excessive temperatures by moving to cool burrows.

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