By A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. Rees MD, MRCP (eds.)
Over the prior decade loads of study task has happened on each side of the gastroduodenal epithelial interface, with the typical target of elucidating the mechanisms of mucosal defense and the way those should be compromised in peptic ulcer ailment. a first-rate stimulus to such learn has been the conclusion that irregular acid secretion or its supply into the duodenum in over the top quantity can't absolutely clarify ulcer pathogenesis within the majority of sufferers. One may well envisage the tummy and proximal duodenum as being in a dynamic equilibrium, with competitive luminal components, similar to acid and pepsin, being counteracted by way of protecting mucosal mechanisms. till lately, the mechanisms concerned about mucosal defense have been poorly outlined whereas the body structure and pathophysiology of acid and pepsin secretion have been elucidated. The effect that gastroduodenal mucosa used to be secure via a unmarried mechanism has eventually been changed via a extra real looking view, suggesting a few protecting zones appearing in sequence. a few of these zones might act as first or moment line defences opposed to competitive elements whereas definite zones may possibly particularly shield opposed to yes aggressors.
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Additional resources for Advances in Peptic Ulcer Pathogenesis
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