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By Alton Meister

Advances in Enzymology and similar components of Molecular Biology is a seminal sequence within the box of biochemistry, delivering researchers entry to authoritative reports of the newest discoveries in all components of enzymology and molecular biology. those landmark volumes date again to 1941, offering an unmatched view of the ancient improvement of enzymology. The sequence bargains researchers the most recent figuring out of enzymes, their mechanisms, reactions and evolution, roles in advanced organic approach, and their program in either the laboratory and undefined. every one quantity within the sequence beneficial properties contributions by way of top pioneers and investigators within the box from around the globe. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.

With its wide variety of issues and lengthy ancient pedigree, Advances in Enzymology and similar parts of Molecular Biology can be utilized not just through scholars and researchers in molecular biology, biochemistry, and enzymology, but in addition through any scientist drawn to the invention of an enzyme, its homes, and its applications.

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And Strosberg, A. , Proc. Natl. Acad. Sci. , 74, 3710 (1977). 17. (a) Limbird, L. , and Lefkowitz, R. , Mol. , 12, 559 (1976); (b) Robert G. , Shorr, Marc G. Caron, and Robert J. Lefkowitz, unpublished data. 18. Lefkowitz, R. , and Caron, M. , Biochem. Biophys. Res. , 60, 703 (1974). 19. Aurbach, G. , Sedak, S. , Woodard, C. , Palmer, J. , Science, 186, 1223 (1974). 20. Lefkowitz, R. ,Proc. Nail. Acad. Sci. , 74, 515 (1977). 21. , and Gilman, A. J. Biol. , 252, 5776 (1977). 22. , and Strosberg, A.

Proc. Natl. Acad. Sci. , 77, 4569 (1980); (b) Hoffman, B. , and Lefkowitz, R. J . , J. Biol. , 255: 4645 (1980). 142. Blume, A. J . , Proc. Natl. Acad. Sci. ,76, 5625 (1979). 143. , and Blume, A,, J. , 5, 367 ( 1979). 144. U’Prichard, D. , and Snyder, S. ,J. Biol. , 253, 3444 (1978). 145. Rosenberg, L. , Yamamura, H. , and Roeske, W. , J. Biol. , 255, 820 (1980). 146. Echlert, F. , Rosenberger, L. , Roeske, W. , and Yamamura, H. , Life Sci. 26, 245 (1980). 147. , and Jakobs, K. , FEBS L e f t .

Histidyl Groups 4. Lysyl Groups 5 . Tyrosyl Groups 6 . Sulfllydryl (Cysteine) Groups B. Distance Measurements by NMR-EPR VI. Conclusions Acknowledgments References 46 47 41 49 50 51 51 53 55 55 57 59 59 63 64 66 61 69 69 69 69 70 70 70 71 12 74 76 76 The literature survey for this review was terminated in May 1980. Margaret M . deMaine is an awardee of an Eloise Gerry Fellowship from Sigma Delta Epsilon. 45 46 STEPHEN I . BENKOVIC AND MARGARET M. deMAINE I. 1 1, D-fructose 1,6-bisphosphate 1-phosphohydrolase; Fru-P2ase) and its substrate provide a fascinating account that illustrates the development of twentieth century biochemistry.

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