By David I. Graham, James A.R. Nicoll, Ian Bone (Eds.)
Advent to Neuropathology 3Ed is still an introductory textual content, yet extra scientific fabric has been brought to make it proper to neurologists and a few psychiatrists, in addition to pathologists. This consists of the addition of small quantities of textual content all through, plus neuroimages, together with sensible MRI, that is in color. moreover, the textual content has been up to date all through with a brand new crew of contributing authors.
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Additional info for Adams & Graham's Introduction to Neuropathology
Anti-thyroid transcription factor (anti-TTF1) for an origin in bronchus, thyroglobulin for an origin in thyroid, and melanan A or HMB-45 for melanoma. Likewise, the presence of chorionic gonadotrophin and ␣1-fetoprotein are important in the identification of cells of trophoblastic origin in 15 germ-cell tumors arising in the region of either the hypothalamus or the pineal gland. It is probably true to say that at present there are no specific immunocytochemical probes for ependyma, although antibodies to carbonic anhydrase C may be used to identify the choroid plexus.
Magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS) and developments in functional imaging: functional MRI (fMRI), positron emission tomography (PET) and single photon emission computed tomography (SPECT), have over the last two decades, corrected many of the earlier dogmas of neurological localization. 1 Normal computed tomography (CT) section through the basal ganglia and occipital lobes showing the low attenuation cerebrospinal fluid (CSF) in the cisterns and ventricles with reasonable gray matter and white matter differentiation and high attenuation in the skull vault.
Infarction, demyelination, tumor or agenesis results in apraxia of movement, the patient having normal power in the limbs but being unable to initiate midline movement and thus unable to walk (gait apraxia). Another form of disconnection occurs when the sensory language cortex, Wernicke’s area, is disconnected from the motor language cortex, 30 Structural and functional neuroanatomy Broca’s area. This results in a form of language disturbance termed conduction aphasia, a characteristic of which is impaired repetition.