By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This e-book is the 7th quantity within the sequence "Acute publicity guide degrees for chosen Airborne Chemicals", and contains AEGLs for acetone cyanohydrin, carbon disulfide, monochloroacetic acid, and phenol. on the request of the dept of safeguard, the nationwide learn Council has reviewed the appropriate clinical literature compiled via a professional panel and proven Acute publicity instruction degrees (AEGLs) for 12 new chemical substances. AEGLs symbolize publicity degrees under which hostile well-being results are usually not more likely to ensue and are important in responding to emergencies equivalent to unintentional or intentional chemical releases in the neighborhood, the office, transportation, the army, and for the remediation of infected websites. 3 AEGLs are authorized for every chemical, representing publicity degrees that bring about: awesome yet reversible ache; long-lasting future health results; and, life-threatening health and wellbeing affects.
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Additional resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 7
Monsanto 1982c 6/24 controls; 24 females tested Red nasal discharge in 12/15 animals vs. 10/15 in controls and perioral wetness/red stain in 4/15 animals vs. 2/15 in controls during first 10-d period; 15 males tested Bloodlike discharge about the nose in 20/30 animals vs. 6/30 in controls and clear nasal discharge in 2/30 animals vs. 0/30 in controls during week 1; no deaths occurred; 15 females and 15 males tested Respiratory distress, prostration, tremors and/or convulsions in 4/20, red nasal discharge in 2/20 animals vs.
8 mmol/kg, respectively (Willhite and Smith 1981). With regard to the metabolism of cyanide, it is important to distinguish between low-dose cyanide metabolism, which occurs under circumstances in which cyanide is present in physiologic concentrations, and high-dose cyanide disposition, in which amounts of cyanide are far in excess of those present under normal physiologic conditions. Low-dose cyanide metabolism involves incorporation via vitamin B12-dependent enzymes of cyanide into the C1-metabolite pool from which it can be eliminated as carbon dioxide.
6 ppm (23 mg/m³) End Point (Reference) Application of AEGL-1 values for HCN (NRC 2002) Application of AEGL-2 values for HCN (NRC 2002) Application of AEGL-3 values for HCN (NRC 2002) a Acetone cyanohydrin decomposes spontaneously in the presence of water to yield HCN and acetone. Therefore, both acetone cyanohydrin and HCN concentrations should be considered. b Cutaneous absorption may occur; direct skin contact with the liquid should be avoided. I. du Pont de Nemours and Co. I. du Pont de Nemours and Co.